Lipopeptides as Dimerization Inhibitors of HIV-1 Protease
نویسندگان
چکیده
منابع مشابه
Lipopeptides as dimerization inhibitors of HIV-1 protease.
In AIDS therapy, attempts have been made to inhibit the virus-encoded enzymes, e.g. HIV-1 protease, using active site-directed inhibitors. This approach is questionable, however, due to virus mutations and the high toxicity of the drugs. An alternative method to inhibit the dimeric HIV protease is the targeting of the interface region of the protease subunits in order to prevent subunit dimeriz...
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ژورنال
عنوان ژورنال: Biological Chemistry
سال: 1999
ISSN: 1431-6730
DOI: 10.1515/bc.1999.076